Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

825
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
825
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.1K
Anatomy of the Intestines01:23

Anatomy of the Intestines

86.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.3K
What is Monogastric Digestion?01:50

What is Monogastric Digestion?

74.7K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
74.7K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

827
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
827
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

756
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
756

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Medical biotechnology and artificial intelligence powered companion diagnostics: indispensable pillars driving next generation precision health care.

Biotechnology letters·2026
Same author

Myeloproliferative Neoplasm With Eosinophilia Exhibiting a Rare GOLGA4-PDGFRB Rearrangement in an Infant: Navigating a Rare Malignancy Amidst Limited Pediatric Guidelines.

Journal of pediatric hematology/oncology·2026
Same author

Complete genomes of <i>Halomonas</i>, <i>Pseudoalteromonas</i>, and <i>Brevibacterium</i> cheese rind bacteria.

Microbiology resource announcements·2026
Same author

Multiomics and tumor banking: comprehensive plaforms- integrating cancer diversity, biomarker discovery and personalised cancer care in India.

Human molecular genetics·2025
Same author

A cytoplasmic form of EHMT1N methylates viral proteins to enable inclusion body maturation and efficient viral replication.

PLoS biology·2024
Same author

Microbiota based personalized nutrition improves hyperglycaemia and hypertension parameters and reduces inflammation: a prospective, open label, controlled, randomized, comparative, proof of concept study.

PeerJ·2024

Related Experiment Video

Updated: Dec 21, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.9K

Gut microbiota and Covid-19- possible link and implications.

Debojyoti Dhar1, Abhishek Mohanty2

  • 1Leucine Rich Bio Pvt Ltd., Bengaluru, India.

Virus Research
|May 21, 2020
PubMed
Summary

The SARS-CoV-2 virus, causing COVID-19, may impact the gut microbiota. Modulating gut bacteria through personalized nutrition and probiotics could be a strategy to mitigate severe COVID-19 outcomes, especially in the elderly.

Keywords:
Covid-19DietDysbiosisGut microbiomeImmunityLung microbiotaSARS-CoV-2

More Related Videos

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.1K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.7K

Related Experiment Videos

Last Updated: Dec 21, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.9K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

10.1K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.7K

Area of Science:

  • Microbiology
  • Immunology
  • Infectious Diseases

Background:

  • The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) primarily infects lung alveolar epithelial cells via ACE2 receptors.
  • SARS-CoV-2 RNA has been detected in the feces of infected individuals, suggesting potential intestinal involvement as enterocytes also express ACE2.
  • Gut microbiota alterations are linked to lung diseases, and respiratory viral infections can disrupt gut microbial composition.

Purpose of the Study:

  • To explore the potential role of gut microbiota in the pathogenesis and severity of COVID-19.
  • To investigate the connection between gut microbiota, aging, and COVID-19 outcomes.
  • To propose gut microbiota modulation as a potential prophylactic strategy against severe COVID-19.

Main Methods:

  • Review of existing literature on SARS-CoV-2, ACE2 receptors, gut microbiota, and immune function.
  • Analysis of the correlation between decreased gut microbiota diversity in the elderly and higher COVID-19 mortality rates.
  • Consideration of dietary factors, environmental influences, and genetics in shaping gut microbiota.

Main Results:

  • The expression of ACE2 receptors in intestinal epithelial cells suggests a potential route for SARS-CoV-2 infection or interaction within the gut.
  • Reduced gut microbiota diversity, common in older individuals, may contribute to increased susceptibility and severity of COVID-19.
  • Gut microbiota perturbations are known to influence systemic immunity, potentially impacting the host's response to SARS-CoV-2 infection.

Conclusions:

  • The gut microbiota may play a significant role in the immune response and overall outcome of COVID-19.
  • Personalized nutrition and supplementation with prebiotics and probiotics could enhance immunity and potentially reduce the impact of COVID-19.
  • Further clinical trials are warranted to evaluate the efficacy of combined functional foods, prebiotics, and probiotics with standard COVID-19 therapies.