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Near-infrared fluorescent solid material for visualizing indwelling devices implanted for medical use.

Takashi Anayama1, Takayuki Sato2, Kentaro Hirohashi3

  • 1Department of Thoracic Surgery, Kochi Medical School, Kochi University, Kohasu Oko, Nankoku, 783-8505, Japan. anayamat@kochi-u.ac.jp.

Surgical Endoscopy
|May 21, 2020
PubMed
Summary

A novel near-infrared fluorescent material offers a less-invasive way to visualize implanted medical devices. This solid resin, superior to indocyanine green, shows promise for clinical applications in medical device visualization.

Keywords:
Device visualizationEndoscopic clipIndwelling ureteral catheterNear-infrared fluorescenceSolid resin material

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Materials Science

Background:

  • Medical implants require X-ray fluoroscopy for visualization, a method with limitations.
  • A less-invasive visualization technique for implanted medical devices is highly desirable in clinical practice.

Purpose of the Study:

  • To investigate the clinical applicability of a novel solid material emitting near-infrared fluorescence for medical device visualization.

Main Methods:

  • A solid resin material incorporating a high-quantum-yield near-infrared fluorescent pigment was developed.
  • The material was sterilized, molded into a catheter, and embedded in a swine model for preclinical testing.
  • Visualization was achieved using a near-infrared fluorescence camera system.

Main Results:

  • The novel near-infrared fluorescent material was successfully visualized in a preclinical swine model.
  • Endoscopic clips and indwelling ureteral catheters were clearly visualized using near-infrared fluorescence laparoscopy.
  • The fluorescence emission demonstrated sufficient tissue permeability.

Conclusions:

  • The developed near-infrared fluorescent material shows potential for clinical application.
  • This material enables visualization of embedded medical devices, offering a less-invasive alternative.
  • Further research can explore broader applications in minimally invasive surgery and diagnostics.