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Radiogenomics and Its Role in Lymphoma
Saman Khan1, Sohaib Naim1, Rania Bilwani1
1Department of Diagnostic Radiology, City of Hope National Cancer Center, 1500 East Duarte Road, Los Angeles, CA, 91010, USA.
Current Hematologic Malignancy Reports
|May 21, 2020
Summary
Imaging characteristics of lymphoma vary by location. Advanced techniques like radiomics and radiogenomics offer new insights into tumor genetics and progression for better lymphoma diagnosis and treatment.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Lymphoma imaging features exhibit regional variations, necessitating site-specific knowledge for accurate staging and timely treatment.
- Conventional imaging modalities like FDG PET/CT and MRI are sensitive and specific for lymphoma diagnosis.
- Emerging PET radiotracers, such as FLT and FET, show potential for enhancing diagnostic specificity.
Purpose of the Study:
- To review the role of imaging in lymphoma diagnosis, staging, and monitoring.
- To highlight the utility of conventional and advanced imaging techniques in characterizing lymphoma.
- To explore the application of radiomics and radiogenomics in understanding lymphoma's genetic landscape.
Main Methods:
- Review of current literature on lymphoma imaging.
- Analysis of data from CT, PET/CT, MRI, and ultrasound in lymphoma assessment.
- Discussion of radiomic and radiogenomic approaches for genetic aberration analysis.
Main Results:
- Site-specific imaging characteristics are crucial for lymphoma staging and treatment.
- FDG PET/CT, MRI, CT, and ultrasound are key modalities for evaluating lymphoma.
- Radiomics and radiogenomics provide noninvasive, real-time surveillance of lymphoma's genetic progression and tumor evolution.
Conclusions:
- Awareness of regional imaging patterns aids lymphoma diagnosis and staging.
- Advanced imaging analysis, including radiogenomics, offers novel insights into lymphoma biology.
- Integrated imaging approaches enhance the noninvasive assessment of lymphoma genetic changes.
