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Updated: Dec 21, 2025

Large-scale Reconstructions and Independent, Unbiased Clustering Based on Morphological Metrics to Classify Neurons in Selective Populations
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The emm-Cluster Typing System

Pierre R Smeesters1,2,3,4, Anne Botteaux5

  • 1Academic Children Hospital Queen Fabiola, Université libre de Bruxelles, Brussels, Belgium. psmeeste@ulb.ac.be.

Methods in Molecular Biology (Clifton, N.J.)
|May 21, 2020
PubMed

Insights

The emm-cluster typing system classifies Streptococcus pyogenes, aiding in epidemiological surveys and vaccine development. This study details how to allocate emm clusters using the emm-typing defining region.

Area of Science:

  • Microbiology
  • Immunology
  • Epidemiology

Background:

  • Streptococcus pyogenes is a significant human pathogen.
  • The emm-cluster typing system categorizes S. pyogenes into 48 distinct clusters.
  • This system correlates with M protein's host serum binding and is vital for research.

Purpose of the Study:

  • To describe the method for allocating emm clusters.
  • To refine the use of the emm-cluster typing system for Streptococcus pyogenes classification.

Main Methods:

  • Utilized the emm-typing defining region for cluster allocation.
  • Applied established emm-cluster typing methodologies.

Main Results:

  • Successfully allocated emm clusters based on the defining region.
  • Demonstrated the utility of this method for Streptococcus pyogenes classification.

Conclusions:

  • The emm-typing defining region provides a reliable basis for emm cluster allocation.
  • This classification method supports ongoing epidemiological surveillance and vaccine development for Streptococcus pyogenes.
Keywords:
M proteinPCRStreptococcus pyogenesemm-cluster typingemm-typing

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