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Fast T2 mapping using multi-echo spin-echo MRI: A linear order approach
Yaghoub Fatemi1, Habibollah Danyali1, Mohammad Sadegh Helfroush1
1Department of Electrical and Electronics Engineering, Shiraz University of Technology, Shiraz, Iran.
Magnetic Resonance in Medicine
|May 21, 2020
Summary
Fast Analysis of Multi-Echo Spin-Echo (FAMESE) accelerates T2 mapping by reducing search space complexity. This novel method provides accurate and reliable T2 measurements, overcoming limitations of conventional techniques.
Area of Science:
- Magnetic Resonance Imaging
- Biomedical Engineering
- Quantitative Imaging
Background:
- Multi-echo spin-echo sequences are standard for T2 mapping.
- Conventional methods overestimate T2 due to stimulated and indirect echoes.
- Accelerated T2 mapping is crucial for clinical applications.
Purpose of the Study:
- Introduce Fast Analysis of Multi-Echo Spin-Echo (FAMESE) as a novel T2 mapping approach.
- Reduce the complexity of the search space for accelerated T2 measurement.
- Improve the accuracy and efficiency of T2 mapping.
Main Methods:
- Developed FAMESE based on mathematical analysis of Bloch equations, reducing search space to one dimension.
- Validated FAMESE in phantom and human brain studies.
- Assessed agreement using Bland-Altman plots and reliability using intraclass correlation coefficients.
Main Results:
- FAMESE demonstrated accelerated and SNR-resistant T2 maps in phantoms and humans.
- Excellent agreement was observed between FAMESE and single-echo spin-echo T2 values.
- High intraclass correlation coefficients (0.9998 for phantom, 0.9860-0.9942 for humans) indicate excellent reliability.
Conclusions:
- FAMESE offers a promising solution for rapid T2 mapping.
- The method achieves clinically feasible scan times.
- FAMESE is a strong candidate for accelerated quantitative T2 imaging.
