Magic angle effect on adiabatic T_1ρ imaging of the Achilles tendon using 3D ultrashort echo time cones trajectory

The protons in collagen-rich musculoskeletal (MSK) tissues such as the Achilles tendon are subject to strong dipolar interactions which are modulated by the term (3cos² θ-1) where θ is the angle between the fiber orientation and the static magnetic field B₀ . The purpose of this study was to investigate the magic angle effect in three-dimensional ultrashort echo time Cones Adiabatic T_1ρ (3D UTE Cones-AdiabT_1ρ ) imaging of the Achilles tendon using a clinical 3 T scanner. The magic angle effect was investigated by Cones-AdiabT_1ρ imaging of five cadaveric human Achilles tendon samples at five angular orientations ranging from 0° to 90° relative to the B₀ field. Conventional Cones continuous wave T_1ρ (Cones-CW-T_1ρ ) and Cones T₂ * (Cones-T₂ *) sequences were also applied for comparison. On average, Cones-AdiabT_1ρ increased 3.6-fold from 13.6 ± 1.5 ms at 0° to 48.4 ± 5.4 ms at 55°, Cones-CW-T_1ρ increased 6.1-fold from 7.0 ± 1.1 ms at 0° to 42.6 ± 5.2 ms at 55°, and Cones-T2* increased 12.3-fold from 2.9 ± 0.5 ms at 0° to 35.8 ± 6.4 ms at 55°. Although Cones-AdiabT_1ρ is still subject to significant angular dependence, it shows a much-reduced magic angle effect compared to Cones-CW-T_1ρ and Cones-T₂ *, and may be used as a novel and potentially more effective approach for quantitative evaluation of the Achilles tendon and other MSK tissues.