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Updated: Dec 21, 2025
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Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
Published on: June 2, 2022
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[ANTIBIOTIC-ASSOCIATED ENCEPHALOPATHY]
Ina Dubin1, Elizabeth Nissim1, Amichai Schattner1,2
1Department of Medicine A, Laniado Hospital, Sanz Medical Center, Netanya.
Harefuah
|May 21, 2020
Summary
Antibiotic-associated encephalopathy (AAE) is a rare adverse drug event linked to antibiotic use. Promptly stopping the causative antibiotic typically resolves symptoms within days.
Area of Science:
- Neurology
- Pharmacology
- Toxicology
Background:
- Antibiotic-associated encephalopathy (AAE) is an uncommon adverse drug event associated with intravenous antibiotic therapy.
- Most antibiotic classes can trigger AAE, with beta-lactams potentially affecting GABA(A) receptors and neurotransmission.
- Risk factors include renal impairment, high drug doses, and pre-existing brain conditions.
Purpose of the Study:
- To report a typical case of antibiotic-associated encephalopathy (AAE).
- To review the existing literature on AAE, including its pathogenesis, clinical presentation, diagnosis, and management.
Main Methods:
- Case report presentation.
- Comprehensive literature review of antibiotic-associated encephalopathy.
Main Results:
- AAE presents with diverse neurological symptoms like altered consciousness, agitation, seizures, and cerebellar signs, often within the first week of antibiotic treatment.
- EEG may show nonspecific triphasic waves; neuroimaging and laboratory tests are typically unrevealing.
- Discontinuation of the implicated antibiotic leads to a median recovery time of 5 days.
Conclusions:
- Increased clinical awareness of AAE is crucial for timely diagnosis and management.
- The syndrome may become more prevalent with the expanding use of antibiotics.
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