Management of radiation-induced ulcers by singlestage reconstructive surgery: a prospective study

Area of Science:

• Plastic Surgery
• Oncology
• Regenerative Medicine

Background:

• Radiation therapy for cancer treatment can lead to late-stage skin reactions, including radiation-induced ulcers.
• These ulcers present a significant challenge in patient care and wound management.
• Effective reconstructive strategies are crucial for improving patient outcomes.

Purpose of the Study:

• To evaluate the efficacy of a single-stage reconstructive procedure for managing radiation-induced ulcers.
• To assess the outcomes and complications associated with immediate reconstruction in a prospective cohort.
• To determine the viability of this approach for patients treated for cancer or hemangioma.

Main Methods:

• A prospective study involving 30 participants with radiation-induced ulcers was conducted.
• Patients underwent various reconstructive procedures including perforator flaps, random-pattern flaps, free flaps, tissue expander flaps, and skin grafts.
• Data collected included patient demographics, ulcer characteristics, reconstructive method, complications, and hospital stay.

Main Results:

• The study included 30 patients (mean age 50 years; 83.3% female) treated between 2013 and 2017.
• A total of 30 reconstructive procedures were performed, with perforator flaps being the most common.
• No instances of recurrence were observed, with only two cases of total flap loss; the median hospital stay was 43 days.

Conclusions:

• Immediate single-stage reconstruction appears to be a valuable and effective option for managing radiation-induced ulcers.
• The reconstructive approach demonstrated a low complication rate and no recurrence, suggesting its potential as a standard treatment.
• This strategy offers a promising solution for patients suffering from radiation-related skin complications.