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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Dec 21, 2025

Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules
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Tick anaphylaxis triggered by pulling out the tick.

Noriya Takayama1, Yusaku Takagaki1

  • 1Susami Municipal Hospital Wakayama Japan.

Acute Medicine & Surgery
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Tick anaphylaxis is rare in Asia. This case highlights a severe allergic reaction in a man after removing a tick, emphasizing cautious removal techniques, especially for those with known allergies.

Keywords:
AnaphylaxisJapanbeeticktick bite

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Area of Science:

  • Allergy and Immunology
  • Toxicology
  • Dermatology

Background:

  • Tick anaphylaxis is a rare but serious allergic reaction.
  • Awareness of tick anaphylaxis is particularly low in Asian countries.
  • This report details a unique case triggered by the physical removal of a tick.

Observation:

  • A 66-year-old man presented with symptoms of anaphylactic shock.
  • The reaction occurred approximately 30 minutes after he manually removed a swollen tick from his toe.
  • Initial symptoms included pruritus followed by chest discomfort and severe hypotension.

Findings:

  • The patient was diagnosed with anaphylactic shock (systolic blood pressure 60 mmHg).
  • Immediate treatment with intramuscular adrenaline was administered.
  • This represents the first reported case of tick anaphylaxis triggered by tick removal in Asia.

Implications:

  • Tick removal should be performed carefully, avoiding pressure on the tick's body.
  • Physicians should consider tick anaphylaxis in patients presenting with allergic reactions, especially after potential tick exposure.
  • Increased awareness and education regarding tick-borne allergies are crucial in endemic regions.