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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Disease diagnostics using hydrodynamic flow focusing in microfluidic devices: Beyond flow cytometry.

Aakash Rajawat¹, Siddhartha Tripathi¹

¹Department of Mechanical Engineering, Birla Institute of Technology and Science, Pilani, K. K. Birla Goa Campus, Zuarinagar, Sancoale, Goa 403726 India.

Biomedical Engineering Letters

|May 21, 2020

Summary

Microfluidics offers rapid analysis with minimal samples. This review explores hydrodynamic focusing for disease diagnosis, monitoring, and drug delivery beyond its typical uses.

Keywords:

Blood DNA Drug delivery Flow cytometer Point-of-care

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Area of Science:

Microfluidics
Biotechnology
Medical Diagnostics

Background:

Microfluidics enables high-throughput, rapid analysis using minimal samples.
Despite advancements in point-of-care devices, its diagnostic applications are underutilized.
Hydrodynamic focusing is a key microfluidic phenomenon with untapped potential.

Purpose of the Study:

To review the applications of hydrodynamic focusing beyond cytometric analysis.
To highlight its potential for disease diagnosis and prognosis.
To explore its use in drug delivery and DNA studies.

Main Methods:

Literature review of scientific publications.
Focus on studies utilizing hydrodynamic focusing for disease detection and monitoring.
Analysis of proposed applications in drug delivery and DNA analysis.

Main Results:

Hydrodynamic focusing shows promise for unambiguous disease detection and monitoring.
Potential applications extend to targeted drug delivery systems.
The technique is applicable to various biological studies, including DNA analysis.

Conclusions:

Hydrodynamic focusing is a versatile microfluidic technique with significant potential for disease diagnostics.
Further research and industry adoption can unlock its full capabilities.
Its applications in monitoring, drug delivery, and DNA studies warrant further investigation.