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The Profiling and Role of miRNAs in Diabetes Mellitus

Michael Kim1, Xiaokan Zhang1

  • 1Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA.

Journal of Diabetes and Clinical Research
|May 21, 2020
PubMed

Insights

MicroRNAs (miRNAs) show altered expression in diabetes mellitus (DM) progression, serving as potential biomarkers. This review highlights their regulatory roles and functional impact in DM pathogenesis.

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Genetics

Background:

  • Diabetes mellitus (DM) is a significant global metabolic health challenge.
  • MicroRNAs (miRNAs) are key post-transcriptional gene regulators.
  • Altered miRNA expression is increasingly linked to DM pathology.

Purpose of the Study:

  • To review recent investigations on miRNA profiles as novel DM biomarkers.
  • To highlight the complex regulatory effects and functional roles of miRNAs in DM.
  • To synthesize findings from clinical studies and animal models.

Main Methods:

  • Literature review of recent scientific investigations.
  • Analysis of studies focusing on miRNA expression signatures in DM.
  • Examination of clinical and animal model data.

Main Results:

  • Specific miRNA expression signatures are altered during DM progression.
  • miRNAs demonstrate potential as diagnostic and prognostic biomarkers for DM.
  • Complex regulatory networks involving miRNAs are crucial in DM pathogenesis.

Conclusions:

  • miRNAs represent promising novel biomarkers for diabetes mellitus.
  • Understanding miRNA functions is vital for elucidating DM mechanisms.
  • Further research into miRNA-based diagnostics and therapeutics is warranted.
Keywords:
Diabetes MellitusmicroRNA

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