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Updated: Aug 18, 2026
Probe-based Real-time PCR Approaches for Quantitative Measurement of microRNAs
Published on: April 14, 2015
Recent progress of SERS optical nanosensors for miRNA analysis
1Department of Chemistry, University of Science & Technology of China, Hefei, Anhui 230026, China. tlitao@ustc.edu.cn and School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, Anhui 243032, China.
Abstract:
This review focuses on emerging applications of surface-enhanced Raman spectroscopy (SERS) optical nanosensors for miRNA analysis, in which the key enhancement factors of the SERS signal, i.e. SERS-active substrates, SERS nanoprobes and nano-assembly strategy, are emphasized. This article includes many nanomaterials for miRNA analysis by the SERS technique. We summarize these reported nanomaterials mainly according to their function in the miRNA assay biosensor. We also briefly summarize the research progress of these nanomaterials in SERS detection of intracellular miRNA. Finally, we discussed the prospect and limitations of SERS nanosensors for analyzing miRNA.
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