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Related Concept Videos

Membrane Domains01:18

Membrane Domains

6.9K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
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Assembly of the Lipid Bilayer in the ER01:28

Assembly of the Lipid Bilayer in the ER

3.9K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
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Membrane Asymmetry Regulating Transporters01:19

Membrane Asymmetry Regulating Transporters

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Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
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Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

3.2K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
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Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

2.2K
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
2.2K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.7K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.7K

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Related Experiment Video

Updated: Dec 21, 2025

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics
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A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

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ENTH domain-dependent membrane remodelling.

Claudia Steinem1, Michael Meinecke

  • 1Institute for Organic and Biomolecular Chemistry, University of Göttingen, Tammannstr. 2, 37077 Göttingen, Germany.

Soft Matter
|May 21, 2020
PubMed
Summary

Cellular membranes dynamically reshape for specific functions. This review focuses on epsin1

Area of Science:

  • Cellular biology
  • Biochemistry

Background:

  • Cellular membranes exhibit complex shapes crucial for physiological functions.
  • Membrane trafficking involves dynamic shape remodeling, exemplified by clathrin-mediated endocytosis.
  • Proteins that sense and induce membrane curvature are vital for these processes.

Purpose of the Study:

  • To review the interaction of the epsin1 ENTH domain with cellular membranes.
  • To highlight epsin1 as a model protein for understanding membrane bending during endocytosis.

Main Methods:

  • Literature review of studies on epsin1 and membrane curvature.
  • Analysis of molecular mechanisms involved in clathrin-mediated endocytosis.

Main Results:

  • The epsin1 ENTH domain is a well-studied example of a peripheral, transient membrane-bending protein.

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  • Numerous membrane remodeling molecules and mechanisms have been identified in endocytosis.

    • Conclusions:

    • Epsin1 plays a significant role in membrane deformation during clathrin-mediated endocytosis.
    • Understanding epsin1-membrane interactions provides insights into fundamental cellular processes.