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Related Concept Videos

Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

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Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Related Experiment Video

Updated: Dec 21, 2025

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

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MitraClip and left ventricular reverse remodelling: a strain imaging study.

Konstantinos Papadopoulos1,2, Ignatios Ikonomidis3, Michael Chrissoheris1

  • 1Transcatheter Heart Valves Department, HYGEIA Hospital, Athens, Greece.

ESC Heart Failure
|May 21, 2020
PubMed
Summary

The MitraClip procedure significantly improves clinical outcomes and reduces left ventricular volumes in patients with functional mitral regurgitation. Preserved global longitudinal strain and global constructive work predict reverse left ventricular remodeling after intervention.

Keywords:
Cardiac mechanicsFunctional mitral regurgitationMitraClip

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Area of Science:

  • Cardiology
  • Medical Devices
  • Echocardiography

Background:

  • Functional mitral regurgitation (FMR) poses significant clinical challenges.
  • The MitraClip device offers a less invasive treatment option for FMR, particularly in high-surgical-risk patients.
  • Predictors of treatment success and reverse left ventricular (LV) remodeling after MitraClip implantation require further elucidation.

Purpose of the Study:

  • To identify echocardiographic predictors of clinical response and reverse LV remodeling in patients with FMR treated with MitraClip.
  • To evaluate the impact of MitraClip implantation on clinical parameters and echocardiographic measures of LV function and strain.

Main Methods:

  • Retrospective analysis of 86 high-surgical-risk patients with severe FMR (58 MitraClip, 28 controls).
  • Clinical and echocardiographic assessments at baseline and 1-year follow-up, including global longitudinal strain (GLS) and myocardial work parameters (GWI, GCW, GWW, GWE).
  • Statistical analysis to identify predictors of LVEDV and LVESV reduction.

Main Results:

  • MitraClip implantation significantly reduced mitral regurgitation, improved NYHA class, BNP levels, and 6-minute walking test distance.
  • The procedure was associated with reduced LV end-systolic (LVESV) and end-diastolic volumes (LVEDV) and improved LV performance, including increased GWI and GCW.
  • Baseline GLS, GWI, GCW, and effective regurgitant orifice area predicted LVEDV reduction; baseline GCW predicted LVESV reduction.
  • A GLS cut-off of -8.65% predicted a 20% LVEDV reduction, and a GCW cut-off of 846 mmHg% predicted a 10% LVESV reduction.

Conclusions:

  • MitraClip repair for FMR yields positive clinical and echocardiographic benefits at 1-year follow-up.
  • Preserved GLS and GCW are associated with favorable LV reverse remodeling post-MitraClip intervention.
  • Echocardiographic parameters like GLS and GCW can predict reverse LV remodeling, aiding in patient selection and outcome prediction.