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Deep Neural Networks for Image-Based Dietary Assessment
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Deep Learning-Based HCS Image Analysis for the Enterprise.

Stephan Steigele1, Daniel Siegismund1, Matthias Fassler1

  • 1Genedata AG, Basel, Switzerland.

SLAS Discovery : Advancing Life Sciences R & D
|May 21, 2020
PubMed
Summary
This summary is machine-generated.

Deep learning image analysis accelerates drug discovery by enabling high-content screening. New software, Genedata Imagence, applies five design principles for reliable phenotypic analysis and knowledge transfer across assays.

Keywords:
cell-based assayshigh-content screeningimage analysisimaging technologiesphenotypic drug discovery

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Area of Science:

  • * Computational biology
  • * Pharmaceutical sciences
  • * Image analysis

Background:

  • * Phenotypic imaging assays offer rich, multiplexed data for drug discovery but present analysis challenges.
  • * Deep learning (DL) can overcome these challenges for high-content imaging (HCI) and multiparameter data.
  • * General DL frameworks are not optimized for automated microscopy images.

Purpose of the Study:

  • * To develop and validate DL-based image analysis for phenotypic screening.
  • * To establish design principles for DL in HCI data analysis.
  • * To introduce Genedata Imagence software for reliable phenotypic endpoint detection and knowledge transfer.

Main Methods:

  • * Optimization of DL networks for automated microscopy images.
  • * Validation across diverse assays with industry partners.
  • * Development of software embodying five key design principles: data representation, training automation, quality control, knowledge transfer, and enterprise integration.

Main Results:

  • * Demonstrated DL-based image analysis is suitable for routine phenotypic screening.
  • * Validated the Genedata Imagence software across multiple assays.
  • * Showcased automated knowledge transfer from trained assays to novel ones.

Conclusions:

  • * DL-based image analysis, guided by specific design principles, is crucial for advancing phenotypic drug discovery.
  • * Genedata Imagence enables reliable detection of drug response, toxicity, and novel phenotypes.
  • * The software facilitates efficient and automated application of expert knowledge to new assays.