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SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities
Marcin F Osuchowski1, Federico Aletti2, Jean-Marc Cavaillon3
1Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Trauma Research Center, Vienna, Austria.
Shock (Augusta, Ga.)
|May 21, 2020
Summary
This review examines the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, addressing knowledge gaps in immunopathogenesis, diagnostics, and translational research for Coronavirus Disease 2019 (COVID-19) treatments.
Area of Science:
- Infectious Diseases
- Immunology
- Translational Medicine
Background:
- The Coronavirus Disease 2019 (COVID-19) pandemic has overwhelmed healthcare systems globally.
- Limited scientific understanding of SARS-CoV-2 pathophysiology hinders effective treatment development.
- Misinformation and data gaps complicate the response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
Purpose of the Study:
- To review current knowledge on SARS-CoV-2 immunopathogenesis and experimental therapies.
- To identify challenges and opportunities in SARS-CoV-2 diagnostics and translational research.
- To propose enhanced international strategies for translational research and regulatory collaboration.
Main Methods:
- Literature review focusing on SARS-CoV-2 immunopathogenesis, diagnostics, and translational technologies.
- Analysis of preclinical evidence for experimental therapies.
- Exploration of potential applications of translational technology in COVID-19 management.
Main Results:
- Significant knowledge gaps exist regarding SARS-CoV-2 immunopathogenesis and effective treatments.
- Translational technologies offer potential for epidemiological prediction, patient monitoring, and treatment decisions.
- Current diagnostic methods face challenges in rapid and accurate detection.
Conclusions:
- There is an urgent need for expanded research into SARS-CoV-2 pathophysiology to guide precise treatments.
- International cooperation in translational research and regulatory processes is crucial for pandemic response.
- Advanced diagnostics and translational technologies are vital for managing the COVID-19 pandemic effectively.
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