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Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
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Classic Hodgkin Lymphoma: A Nonclassic Presentation.
Monica Mattes1, Amy Steele2, Jong Chung3
1Department of Pediatrics, University of California Davis Medical Center.
Journal of Pediatric Hematology/Oncology
|May 21, 2020
Summary
Hodgkin lymphoma typically causes swollen lymph nodes and B symptoms. This case highlights a rare presentation of localized back pain, emphasizing the need for broad differentials in young patients with bone lesions.
Area of Science:
- Oncology
- Hematology
- Radiology
Background:
- Hodgkin lymphoma classically presents with lymphadenopathy and B symptoms.
- It is a potentially curable malignancy with prompt diagnosis and treatment.
- Typical spread is contiguous, involving lymph node chains.
Observation:
- This report details a unique case of Hodgkin lymphoma.
- The patient presented with localized back pain as the primary symptom.
- Overt lymph node involvement was not initially evident.
Findings:
- The case demonstrates a nonclassical presentation of Hodgkin lymphoma.
- Lytic bone lesions were identified in the patient.
- The presentation mimicked other bone pathologies, posing a diagnostic challenge.
Implications:
- This case underscores the importance of a broad differential diagnosis.
- Clinicians should consider Hodgkin lymphoma in adolescents and young adults with unexplained localized pain and lytic bone lesions.
- Early recognition of atypical presentations is crucial for timely and effective treatment.
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