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Updated: Dec 21, 2025

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs
05:40

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

494

A trial comparing continuous positive airway pressure (CPAP) devices in preterm infants

Carl H Backes1,2,3, Jennifer N Cooper4,5,6, Jennifer L Notestine7

  • 1Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Carl.backesjr@nationwidechildrens.org.

Journal of Perinatology : Official Journal of the California Perinatal Association
|May 21, 2020
PubMed

Insights

This study found no significant difference in continuous positive airway pressure (CPAP) failure rates between Seattle-PAP and Fisher&Paykel-CPAP (FP-CPAP) for preterm infants. Both devices demonstrated similar efficacy in supporting respiratory function in neonates born before 30 weeks

Area of Science:

  • Neonatal Medicine
  • Respiratory Support
  • Clinical Trials

Background:

  • Preterm infants born before 30 weeks' gestation often require respiratory support.
  • Continuous positive airway pressure (CPAP) is a common non-invasive ventilation method.
  • Comparing different CPAP delivery systems is crucial for optimizing neonatal care.

Purpose of the Study:

  • To evaluate if Seattle-PAP reduces continuous positive airway pressure (CPAP) failure rates compared to Fisher&Paykel-CPAP (FP-CPAP).
  • To assess the efficacy of Seattle-PAP in infants born <30 weeks' gestation.

Main Methods:

  • A randomized trial was conducted across 5 NICUs from March 2017 to January 2019.
  • 232 infants born <30 weeks' gestation were randomized to either Seattle-PAP or FP-CPAP.
  • The primary outcome was CPAP failure, with subgroup analyses based on gestational age and antenatal corticosteroid use.

Main Results:

  • No significant difference in CPAP failure rates was observed between Seattle-PAP (35.7%) and FP-CPAP (31.7%).
  • Risk difference was 4.1% (95% CI, -8.1-16.2; P=0.51).
  • Subgroup analyses, adverse events, and duration of respiratory support also showed no significant differences between the groups.

Conclusions:

  • Seattle-PAP and FP-CPAP demonstrate comparable effectiveness in preventing CPAP failure for infants born <30 weeks' gestation.
  • Neither device showed superiority in terms of treatment failure or adverse events.
  • Current evidence suggests similar clinical outcomes for both CPAP systems in this vulnerable population.
Abstract

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