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Relationship between QT/QS2 ratio and angiographic severity of coronary heart disease

S Cuomo1, D Acanfora, M Papa

  • 1Servizio di Cardiologia, Centro Traumatologico Ortopedico, Napoli.

Giornale Italiano Di Cardiologia
|August 1, 1988
PubMed

Insights

The QT/QS2 ratio, a measure of cardiac function, is higher in patients with coronary heart disease (CHD) and abnormal left ventricular wall motion. A QT/QS2 ratio above 0.99 may indicate CHD in patients with chest pain.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Diagnostic Imaging

Background:

  • Coronary heart disease (CHD) poses a significant global health burden.
  • Accurate and non-invasive diagnostic tools for CHD are crucial for timely intervention.
  • Systolic time intervals, including the QT/QS2 ratio, reflect cardiac function and may correlate with cardiac disease severity.

Purpose of the Study:

  • To investigate the relationship between the QT/QS2 ratio and the angiographic severity of coronary heart disease.
  • To assess the diagnostic utility of the QT/QS2 ratio in identifying CHD in patients presenting with chest pain.

Main Methods:

  • Ninety-nine patients undergoing coronary arteriography for chest pain were studied.
  • QT/QS2 ratio and systolic time intervals were calculated from polysomnographic recordings at rest.
  • Comparison was made between patients with CHD and a control group with normal coronary arteriograms.

Main Results:

  • The QT/QS2 ratio was significantly higher in patients with double and triple vessel coronary artery disease compared to controls.
  • A higher QT/QS2 ratio correlated with an increased number of left ventricular abnormal wall motion (LV AWM) segments.
  • The QT/QS2 ratio showed 30% sensitivity, 94% specificity, and 96% predictive accuracy for diagnosing CHD when using a threshold of 0.99.

Conclusions:

  • The QT/QS2 ratio in patients with CHD is influenced by the extent of left ventricular abnormal wall motion.
  • While its sensitivity is limited, a QT/QS2 ratio exceeding 0.99 is a strong indicator of CHD in patients with chest pain, suggesting its potential diagnostic value.

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