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Related Experiment Video

Updated: Dec 21, 2025

Measurement of the Pressure-volume Curve in Mouse Lungs

Measurement of the Pressure-volume Curve in Mouse Lungs

Published on: January 27, 2015

Lung Volume Reduction in Pulmonary Emphysema.

Justin L Garner^1,2,3, Pallav L Shah^1,2,3

¹Department of Respiratory Medicine, Royal Brompton Hospital, London, United Kingdom.

Seminars in Respiratory and Critical Care Medicine

|May 21, 2020

Summary

This summary is machine-generated.

New lung volume reduction techniques offer less invasive options for severe emphysema patients. Bronchoscopic lung volume reduction, including valves and coils, shows promise for improving quality of life and exercise capacity.

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Area of Science:

Pulmonology
Thoracic Surgery
Medical Devices

Background:

Severe emphysema with hyperinflation poses significant treatment challenges.
Inhaled therapies have limited efficacy due to respiratory mechanics and gas exchange issues.
Lung volume reduction surgery (LVRS) improves outcomes but has high early morbidity.

Purpose of the Study:

To review emerging bronchoscopic lung volume reduction technologies.
To evaluate the efficacy and safety of novel emphysema treatments.
To compare these techniques to traditional LVRS.

Main Methods:

Review of clinical data for endobronchial valves and coils.
Analysis of segmental delivery methods (vapor, sealant).
Assessment of outcomes in selected emphysema patient cohorts.

Main Results:

Endobronchial valves show comparable outcomes to LVRS in selected patients.
Endobronchial coils are viable for severe hyperinflation with collateral ventilation.
Limited data exists for vapor and sealant modalities.

Conclusions:

Bronchoscopic lung volume reduction offers a less invasive alternative to LVRS.
Endobronchial valves and coils are established options for specific emphysema types.
Further research is needed for vapor and sealant technologies.