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Updated: Dec 21, 2025
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
Mice with humanized-lungs and immune system - an idealized model for COVID-19 and other respiratory illness
Sujit Pujhari1, Jason L Rasgon1
1Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences.
Abstract:
Lack of an appropriate animal model to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent responsible for COVID-19 pandemic disease, represents a significant hurdle in the process of understanding disease biology and evaluating therapeutic and preventive candidates. It is time for public health agencies to revisit regulation on transplantation of human pluripotent stem cells for the possibility of the development of a humanized mice model with a humanized lung.
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