Evaluating delirium outcomes among older adults in the surgical intensive care unit

Kara J Pavone1, Juliane Jablonski2, Paul Junker2

  • 1School of Nursing, Northeastern University, 360 Huntington Ave, Robinson Hall, Boston, MA 02115, United States.

Abstract

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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