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Related Concept Videos

RNA Splicing01:32

RNA Splicing

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA Splicing02:18

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Nucleotide Excision Repair01:38

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DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Related Experiment Video

Updated: Dec 21, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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RNA Splicing and Cancer.

Eric Wang1, Iannis Aifantis1

  • 1Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.

Trends in Cancer
|May 22, 2020
PubMed
Summary
This summary is machine-generated.

Cancer cells exploit RNA splicing for growth by altering gene regulation and hijacking RNA-binding proteins. This review covers splicing alterations in cancer and potential immunotherapies targeting tumor-specific splicing changes.

Keywords:
AMLRBPsimmunotherapyneoantigenspliceosomesplicing

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Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • RNA splicing is crucial for cellular functions like proliferation, survival, and differentiation.
  • Aberrant RNA splicing is linked to human cancer development and progression.
  • Cancer cells manipulate RNA splicing machinery and RNA-binding proteins (RBPs) to promote tumorigenesis.

Purpose of the Study:

  • To review the mechanisms by which cancer cells exploit RNA splicing.
  • To discuss the role of splicing machinery mutations and RBPs in cancer.
  • To explore tumor-specific splicing alterations and their potential as immunotherapeutic targets.

Main Methods:

  • Review of existing literature on RNA splicing in cancer.
  • Analysis of genomic studies identifying splicing machinery mutations.
  • Examination of next-generation RNA sequencing data for tumor-specific isoforms and neoantigens.

Main Results:

  • Cancer cells utilize altered RNA splicing to enhance proliferation and survival.
  • Mutations in splicing factors and dysregulated RBPs contribute to tumorigenesis.
  • Tumor-specific RNA isoforms, including neoantigens, are identified as potential therapeutic targets.

Conclusions:

  • RNA splicing is a critical regulatory pathway frequently dysregulated in cancer.
  • Targeting cancer-specific splicing vulnerabilities offers a promising therapeutic strategy.
  • Splicing-based therapies, including those targeting neoantigens, are emerging as a new frontier in cancer treatment.