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Updated: Dec 21, 2025
07:20
Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
Published on: January 14, 2011
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Effects of B cell-activating factor on tumor immunity
JCI Insight
|May 22, 2020
Summary
B cell-activating factor (BAFF) enhances antitumor immunity by boosting T cell activation and promoting a memory phenotype. BAFF signaling shows promise as a novel cancer immunotherapy strategy, improving patient survival.
Area of Science:
- Immunology
- Oncology
- Cancer Immunotherapy
Background:
- T cell-based immunotherapies are established cancer treatments.
- The role of B cells in antitumor immunity is less understood.
- B cell-activating factor (BAFF) is a TNF ligand family cytokine with known roles in autoimmunity but unclear effects on cancer immunity.
Purpose of the Study:
- To investigate the role of BAFF in antitumor immunity.
- To determine BAFF's effects on B cell function and T cell responses in cancer.
- To explore BAFF as a potential cancer immunotherapy.
Main Methods:
- In vitro studies of B cell costimulatory molecule expression and antigen presentation.
- Syngeneic mouse melanoma model to assess BAFF's in vivo effects on immune cells and antitumor immunity.
- Analysis of The Cancer Genome Atlas (TCGA) human melanoma data.
Main Results:
- BAFF upregulates B cell costimulatory molecules, IL-12a expression, and antigen presentation in vitro.
- In vivo, BAFF enhances T cell activation, TH1 polarization, CCR6 expression, and memory phenotype, leading to improved antitumor immunity.
- BAFF promotes regulatory T cell (Treg) expansion and is associated with improved survival and TH1/IFN-γ signatures in human melanoma.
Conclusions:
- BAFF enhances antitumor immunity through modulation of B and T cell functions.
- Adjuvant BAFF improves vaccine efficacy and promotes T cell memory.
- BAFF signaling represents a promising avenue for cancer immunotherapy development.
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