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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
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CRNDE: an oncogenic long non-coding RNA in cancers.
Ya Lu1,2, Huanhuan Sha1,2, Xun Sun1,2
11Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Baiziting42, 210009 Nanjing, China.
Cancer Cell International
|May 22, 2020
Summary
Colorectal neoplasia differentially expressed (CRNDE), a long non-coding RNA, is upregulated in various cancers. This review explores CRNDE's functions and mechanisms, highlighting its potential as a cancer biomarker.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Colorectal neoplasia differentially expressed (CRNDE) is a long non-coding RNA (lncRNA).
- CRNDE is frequently upregulated across diverse cancer types.
- Emerging evidence implicates CRNDE in various cancer biological processes.
Purpose of the Study:
- To review the biological functions of CRNDE in cancer.
- To elucidate the molecular mechanisms underlying CRNDE's role in cancer.
- To establish a molecular foundation for CRNDE's potential clinical applications.
Main Methods:
- Literature review of studies on CRNDE in cancer.
- Analysis of published data on CRNDE expression and function.
- Synthesis of information regarding CRNDE's involvement in cancer biology.
Main Results:
- CRNDE exhibits differential expression in neoplastic tissues compared to normal tissues.
- CRNDE participates in critical cellular pathways relevant to tumorigenesis.
- Studies suggest CRNDE possesses high sensitivity and specificity as a biomarker.
Conclusions:
- CRNDE plays significant roles in the development and progression of various cancers.
- CRNDE holds promise as a diagnostic biomarker and prognostic predictor.
- Further research into CRNDE mechanisms can facilitate its clinical translation.
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