Relation between Febrile Seizure Recurrence and Hyponatremia in Children: A Single-center Trial
Mohammad Reza Navaeifar1, Ali Abbaskhanian1, Akram Farmanbarborji2
1Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Insights
Lower serum sodium levels were more common in children experiencing febrile seizures (FS) compared to those without fever. This study investigated serum sodium in simple and recurrent FS cases.
Area of Science:
- Pediatric Neurology
- Clinical Chemistry
Background:
- Febrile seizure (FS) is a prevalent neurological event in pediatric populations.
- Understanding the metabolic factors associated with FS is crucial for clinical management.
Purpose of the Study:
- To compare serum sodium levels in children with simple or recurrent febrile seizures (FS) versus those with afebrile seizures.
- To investigate the association between serum sodium concentration and the occurrence of febrile seizures.
Main Methods:
- A cross-sectional prospective study involving 248 children aged 6 months to 6 years.
- Patients were divided into three groups: simple FS, recurrent FS, and afebrile seizure.
- Serum sodium levels were measured upon admission and/or during seizure events.
Main Results:
- Hyponatremia was observed in 6% of simple FS, 7.5% of recurrent FS, and 6% of afebrile seizure groups.
- Mean serum sodium levels were significantly lower in both simple and recurrent FS groups compared to the afebrile seizure group.
- No significant difference in mean sodium levels was found between simple and recurrent FS groups.
Conclusions:
- Lower serum sodium concentration is more frequently observed in children with febrile seizures.
- The study did not establish a direct link between lower serum sodium and increased seizure recurrence risk within 24 hours during febrile illness.
Background:
Febrile seizure (FS) is one of the most common types of seizure in pediatrics.
Objective:
The aim of this study was to compare serum sodium in children with simple or recurrent FS and seizure without fever.
Materials And Methods:
This was a cross-sectional prospective study conducted between September 2015 and April 2017 in patients aged between 6 months and 6 years, who were admitted to a tertiary educational medical center in the north of Iran. Patients were categorized into three groups, group A: simple FS, group B: recurrent FS, and group C: afebrile seizure. Serum sodium level was measured on admission and/or when the seizure occurred.
Results:
The study included 248 patients aged 6 months to 6 years. Their mean age was 22.38 ± 1.34 months. Hyponatremia was found in 6% of group A, 7.5% of group B, and 6% of group C. The mean sodium level in group A (134.46 ± 2.3 mEq/L) and group B (134.35 ± 2.06 mEq/L) did not disclose meaningful difference, but it was significantly lower in febrile groups than in the control group.
Conclusion:
Although the results did not show that the lower level of serum sodium increased the risk of seizure recurrence during the next 24h in febrile illness, lower serum sodium concentration was more common in FS groups.
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