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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

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Related Experiment Video

Updated: Jun 27, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice
07:56

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

Malignant hyperpyrexia.

C R Stephen

    Annual Review of Medicine
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Malignant hyperpyrexia is a rare genetic disorder triggered during anesthesia. Prompt treatment with dantrolene sodium is crucial for managing this life-threatening condition.

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    Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

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    Related Experiment Videos

    Last Updated: Jun 27, 2026

    Protocol for Long Duration Whole Body Hyperthermia in Mice
    07:56

    Protocol for Long Duration Whole Body Hyperthermia in Mice

    Published on: August 25, 2012

    Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
    06:43

    Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

    Published on: November 21, 2017

    Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
    13:41

    Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

    Published on: January 13, 2023

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Genetics

    Background:

    • Malignant hyperpyrexia is a severe, genetically influenced hypermetabolic crisis.
    • It is typically triggered by specific anesthetic agents.
    • Reliable prediction before anesthesia is challenging, often relying on family history.

    Purpose of the Study:

    • To highlight the critical nature of malignant hyperpyrexia.
    • To discuss potential triggers and the underlying pathophysiology.
    • To emphasize the importance of prompt and specific treatment.

    Main Methods:

    • Review of existing literature on malignant hyperpyrexia.
    • Discussion of suspected etiological factors, particularly calcium release.
    • Emphasis on clinical diagnosis and immediate therapeutic interventions.

    Main Results:

    • Malignant hyperpyrexia presents as a medical emergency requiring immediate action.
    • Calcium release from sarcoplasmic reticulum is a key suspected mechanism.
    • Dantrolene sodium is identified as a specific and effective therapeutic agent.

    Conclusions:

    • Malignant hyperpyrexia necessitates urgent and aggressive management.
    • Understanding triggering agents and pathophysiology is vital.
    • Dantrolene sodium offers a critical treatment option for anesthetic practice.