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Verification Study of Residual Activity Measurements After Yttrium-90 Radioembolization with Glass Microspheres
S C Ebbers1, B Kunnen2, B J van Nierop2
1Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3508 GA, Utrecht, The Netherlands. s.c.ebbers-2@umcutrecht.nl.
Cardiovascular and Interventional Radiology
|May 22, 2020
Summary
The survey meter method for measuring residual yttrium-90 (90Y) microsphere activity after radioembolization is inaccurate. PET/CT or dose calibrator measurements are more reliable for quantifying residual activity.
Area of Science:
- Nuclear medicine
- Radiology
- Medical physics
Background:
- Radioembolization with yttrium-90 (90Y) microspheres is a common treatment.
- Accurate measurement of residual 90Y activity is crucial for dosimetry.
- Current methods for measuring residual activity lack sufficient validation.
Purpose of the Study:
- To verify the accuracy of the survey meter approach for measuring residual 90Y glass microsphere activity.
- To compare survey meter measurements with PET/CT and dose calibrator measurements.
- To assess the reliability of standard residual activity measurement protocols.
Main Methods:
- Prospective scanning of 24 waste containers using 90Y-PET/CT.
- Comparison of residual activity measurements obtained by survey meter, PET/CT, and dose calibrator.
- Bland-Altman analysis to assess agreement between measurement methods.
Main Results:
- Substantial disagreement was observed between survey meter and PET/CT measurements.
- Significant discrepancies were also found between survey meter and dose calibrator measurements.
- Excellent correlation (ρ = 0.99) was found between PET/CT and dose calibrator measurements.
Conclusions:
- The survey meter method significantly underestimates or overestimates residual 90Y microsphere activity.
- PET/CT or dose calibrator measurements are more accurate for quantifying residual activity.
- Consider alternative quantification methods if high residual activity is detected with a survey meter.
