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Primary Cutaneous CD30+ Lymphoproliferative Disorders: a Comprehensive Review
Cosimo Di Raimondo1, Vishwas Parekh1, Joo Y Song1
1City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA.
Current Hematologic Malignancy Reports
|May 22, 2020
Summary
Primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPDs) are common skin lymphomas. This review consolidates evidence for accurate diagnosis and treatment of these conditions.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Primary cutaneous CD30+ T-cell lymphoproliferative disorders (CD30+ LPDs) are the second most frequent cutaneous lymphomas.
- These disorders encompass primary cutaneous anaplastic large cell lymphoma (pcALCL), lymphomatoid papulosis (LyP), and borderline lesions.
Purpose of the Study:
- To consolidate existing evidence on primary cutaneous CD30+ LPD.
- To define diagnostic tools and appropriate treatment strategies for CD30+ LPDs.
Main Methods:
- Comprehensive literature review.
- Analysis of clinical features, histopathology, genetic alterations, and therapeutic options.
Main Results:
- CD30+ LPDs exhibit significant histologic overlap with other entities.
- Accurate differentiation is crucial due to varying clinical courses and prognoses.
Conclusions:
- A consolidated understanding of CD30+ LPDs aids in precise diagnosis.
- Tailored treatment approaches are essential for managing these rare cutaneous lymphomas.
