Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

31.7K
Overview
31.7K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

1.6K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.6K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.0K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.0K
Cross-reactivity00:42

Cross-reactivity

32.7K
Overview
32.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Variation in Timing of Allergenic Food Introduction for Food Allergy Prevention: An International Survey of Healthcare Professionals.

Allergy·2026
Same author

IgE-Mediated Legume Allergy in Children: Insights from a Single-Center Experience in Italy.

Nutrients·2026
Same author

Editorial comment: Beyond teasing-Food allergy-related bullying as a school health and equity priority.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Exploring drug hypersensitivity in children with chronic spontaneous Urticaria: A comprehensive analysis using diagnostic tests.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same author

Pragmatic Strategies for Reducing Variability and Risk in Food Oral Immunotherapy.

Clinical reviews in allergy & immunology·2026
Same author

Algorithms in Allergy: Elevated IgE in Pediatric Patients.

Allergy·2026
Same journal

Phenotypes of atopic dermatitis in Polish children-Latent class analysis of cross-sectional questionnaire-based study.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Comment on Elhani et al.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Bridging Rare to Common Diseases: Precision Medicine and the Transforming Landscape of Pediatric Allergy and Immunology.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Involution of IgE sensitization to house dust mite allergen molecules by age.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

Early initiation of inhaled corticosteroid-long-acting β<sub>2</sub>-agonist therapy and reduction of severe asthma exacerbations in high-risk preschool children: A longitudinal real-world cohort study.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
Same journal

The role of dog keeping in the home microbiota and its impact on children's health.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026
See all related articles

Related Experiment Video

Updated: Dec 21, 2025

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K

EAACI Allergen Immunotherapy User's Guide.

Montserrat Alvaro-Lozano1, Cezmi A Akdis2,3, Mubeccel Akdis2

  • 1Pediatric Allergy and Clinical Immunology Service, Hospital Sant Joan de Déu, Barcelona, Spain.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|May 22, 2020
PubMed
Summary
This summary is machine-generated.

Allergen immunotherapy effectively treats allergic children by regulating immune responses. This guide helps healthcare professionals choose the best treatment methods and highlights areas for future improvement in pediatric allergy care.

Keywords:
Allergyimmune regulationimmunotherapytolerance

More Related Videos

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.8K
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.3K

Related Experiment Videos

Last Updated: Dec 21, 2025

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K
Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
07:10

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE

Published on: April 21, 2019

16.8K
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.3K

Area of Science:

  • Immunology
  • Pediatrics
  • Allergy

Background:

  • Allergen immunotherapy (AIT) is a key treatment for allergic children.
  • It works by inducing regulatory T cells and reducing allergic reactions.
  • Established indications include respiratory allergies (pollens, dust mites) and Hymenoptera venom anaphylaxis.

Purpose of the Study:

  • To review current knowledge on AIT in children.
  • To provide clinical guidance for healthcare professionals.
  • To identify areas for AIT improvement in pediatric populations.

Main Methods:

  • Review of existing literature on allergen immunotherapy in children.
  • Analysis of current administration methods (subcutaneous and sublingual).
  • Discussion of clinical indications and patient profiles.

Main Results:

  • AIT relies on specific immunologic mechanisms for efficacy.
  • Both subcutaneous and sublingual administration have distinct advantages and disadvantages.
  • Patient profile is crucial for selecting the optimal administration route.

Conclusions:

  • Further research is needed to identify biomarkers predicting AIT success.
  • Development of improved adjuvants and novel formulations could enhance treatment efficacy and adherence.
  • This guide aims to support healthcare professionals in managing pediatric AIT.