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Evaluation of thiol/disulfide homeostasis in patients with gestational diabetes mellitus

Suat Cakina1, Buket Aydın2, Fatma Beyazit2

  • 1Health Service Vocational College, Canakkale 18 Mart University, Canakkale, Turkey.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
|May 22, 2020
PubMed

This study aimed to study the dynamic thiol/disulfide homeostasis in pregnant women with gestational diabetes mellitus (GDM). Forty-five pregnant women with GDM and 45 age-matched healthy pregnancies were included in this study. Thiol/disulfide homeostasis was measured using a commercial kit (Rel Assay Diagnostics). The patients with GDM had significantly higher disulfide concentrations than healthy pregnant patients (p = .001). Besides, the GDM group had significantly higher disulfide/total thiol, disüplhide/native thiol, and native thiol/total thiol ratio than healthy pregnant patients (p = .001, p = .001 and p = .001, respectively). The significantly higher concentrations of disulfide, disulfide/total thiol, disüplhide/native thiol, and native thiol/total thiol ratio in women with GDM could be considered as the increased oxidative stress.

Keywords:
Oxidative stressgestational diabetes mellitusthiol/disulfide homeostasis

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