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Dual-responsive self-assembly in lysosomes enables cell cycle arrest for locking glioma cell growth
Jie Zhan1, Jing Zhong, Shaodan Ma
1Shunde Hospital, Southern Medical University, the First People's Hospital of Shunde, Foshan 528300, P. R. China.
Abstract:
Herein we first report a dual-responsive peptide substrate (Comp. 1) for preparing self-assembled nanomaterials triggered by pH and legumain. The dual-responsive self-assembly of Comp. 1 in glioma cells enables its long retention time in lysosomes, S phase arrest, and cell growth locking. We verified that the blocked degradation of HIF-1α in lysosomes played a key role in cell cycle arrest and decreased DNA replication. This work illustrates the disturbance of lysosomal function by self-assembled nanomaterials as a promising strategy for inhibiting glioma cell growth.
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