Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Venous waterfalls mainly buffer backward pressure transmission.

Intensive care medicine experimental·2026
Same author

Cardiovascular and Autonomic Phenotypes Reveal Distinct Mechanisms of Sepsis Decompensation via Deep Learning.

Research square·2026
Same author

Venous congestion from a vascular waterfall perspective: reframing congestion as a dynamic Starling resistor phenomenon.

Intensive care medicine experimental·2025
Same author

Right ventricle and venous system: bridging physiology and clinical practice. A narrative review.

Critical care science·2025
Same author

European Society of Intensive Care Medicine (ESICM) 2025 clinical practice guideline on fluid therapy in adult critically ill patients: part 2-the volume of resuscitation fluids.

Intensive care medicine·2025
Same author

Is Pulmonary Vascular Resistance in Acute Respiratory Distress Syndrome the Judge Defining Recruitment versus Overdistention with Positive End-Expiratory Pressure?

American journal of respiratory and critical care medicine·2024

Related Experiment Video

Updated: Dec 20, 2025

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model
07:56

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model

Published on: May 18, 2021

4.0K

Dynamic right and left ventricular interactions in the pig.

Michael R Pinsky1

  • 1Cardiopulmonary Research Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Experimental Physiology
|May 22, 2020
PubMed
Summary

Ventricular interdependence mechanisms differ based on pressure loading. Increased left ventricular pressure affects right ventricular function independently of the pericardium, while increased right ventricular pressure impacts left ventricular compliance, depending on the pericardium.

Keywords:
contractilitydyssynchronyelastancepericardiumporcine modelright ventricular functionventricular interdependence

More Related Videos

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.5K
Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.4K

Related Experiment Videos

Last Updated: Dec 20, 2025

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model
07:56

Closed Chest Biventricular Pressure-Volume Loop Recordings with Admittance Catheters in a Porcine Model

Published on: May 18, 2021

4.0K
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.5K
Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS
08:12

Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

Published on: November 26, 2018

10.4K

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Mechanics
  • Ventricular Interaction

Background:

  • Ventricular interdependence describes how the pressure-volume mechanics of one ventricle influence the other.
  • The pericardium's role in modulating ventricular interdependence under varying pressure loads is not fully elucidated.
  • Understanding these dynamics is crucial for diagnosing and managing conditions involving altered cardiac pressures.

Purpose of the Study:

  • To investigate the distinct mechanisms of ventricular interdependence under primary right ventricular versus left ventricular pressure loading.
  • To determine the influence of the pericardium on these pressure-load-induced ventricular interactions.
  • To assess the role of contraction synchrony in mediating these effects.

Main Methods:

  • Simultaneous measurement of right ventricular (RV) and left ventricular (LV) pressures and volumes using conductance catheters in anesthetized piglets.
  • Assessment of ventricular interdependence during various occlusions (aortic, pulmonary artery, vena cava) and fluid loading.
  • Evaluation of regional contractile synchrony using conductance catheter-derived long-axis regional volumes.

Main Results:

  • An acute increase in left ventricular pressure (via aortic occlusion) elevated RV end-systolic pressure and elastance, independent of the pericardium.
  • An acute increase in right ventricular pressure (via pulmonary artery occlusion) decreased LV diastolic compliance, dependent on an intact pericardium.
  • Neither ventricular pressure increase altered contraction synchrony.

Conclusions:

  • The determinants of systolic and diastolic ventricular interdependence are distinct.
  • Right ventricular pressure increases primarily cause diastolic RV-to-LV interdependence, reducing LV diastolic compliance and requiring an intact pericardium.
  • Left ventricular pressure increases primarily affect RV systolic function (elastance) independently of the pericardium, with minimal impact on RV diastolic function or synchrony.