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Updated: Dec 20, 2025

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy
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Platelet function in cats with hyperthyroidism.

Elizabeth C Hiebert1, David L Panciera1, Katie M Boes2

  • 1Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.

Journal of Feline Medicine and Surgery
|May 22, 2020
PubMed
Summary
This summary is machine-generated.

Hyperthyroid cats did not show altered platelet function, measured by closure time, compared to healthy cats. However, hyperthyroid cats had a higher platelet count, suggesting further research into feline hypercoagulable states.

Keywords:
C-ADPPFA-100Platelet function analyzercollagen adenosine diphosphatethromboembolismthyroid

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Area of Science:

  • Veterinary Medicine
  • Cardiovascular Physiology
  • Hematology

Background:

  • Hyperthyroidism in cats is associated with thromboembolic events.
  • The role of platelet function in feline hyperthyroidism-related thromboembolism is not fully understood.

Purpose of the Study:

  • To compare platelet function in hyperthyroid cats with age-matched euthyroid cats.
  • To investigate if hyperthyroidism shortens collagen and adenosine diphosphate (C-ADP) closure times.

Main Methods:

  • Platelet function was assessed using the platelet function analyzer (PFA-100) measuring C-ADP closure times.
  • Platelet counts were also measured in 16 hyperthyroid and 9 euthyroid cats over 7 years of age.

Main Results:

  • No significant difference in C-ADP closure times was observed between hyperthyroid and control cats.
  • Hyperthyroid cats exhibited a significantly higher mean platelet count compared to controls.
  • Treatment duration with methimazole did not significantly affect closure times.

Conclusions:

  • Platelet function, under high shear conditions with C-ADP, is not affected by hyperthyroidism in this feline cohort.
  • Further investigation is warranted to explore potential hypercoagulable states and the roles of platelets and von Willebrand factor in hyperthyroid cats.