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Related Experiment Videos

Tocopherol concentrations in platelets in children.

K Tatsumi1, K Yaoi, M Mino

  • 1Department of Pediatrics, Osaka Medical College, Takatsuki, Japan.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|January 1, 1988
PubMed
Summary
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This study establishes normal platelet tocopherol (vitamin E) ranges in children, finding lower levels in older children compared to adults and infants. Infants showed adult-comparable vitamin E levels, potentially due to formula intake.

Area of Science:

  • Biochemistry
  • Pediatric Nutrition
  • Clinical Chemistry

Background:

  • Tocopherol (vitamin E) is a vital lipid-soluble antioxidant.
  • Establishing pediatric reference ranges for tocopherol is crucial for nutritional assessment.
  • Previous studies have not fully characterized platelet tocopherol concentrations across pediatric age groups.

Purpose of the Study:

  • To determine the normal range of platelet tocopherol concentrations in healthy children aged 3 months to 15 years.
  • To compare pediatric platelet and plasma tocopherol levels with adult values.
  • To investigate tocopherol concentrations in infants versus older children.

Main Methods:

  • Analysis of platelet tocopherol concentrations in 158 healthy children (3 months-15 years).

Related Experiment Videos

  • Comparison of pediatric data with adult reference values.
  • Assessment of plasma and red blood cell (RBC) tocopherol levels and tocopherol/lipid ratios.

    • Main Results:

    • Mean platelet tocopherol concentration in children was 0.17 µg/mg protein (range: 0.07-0.39 µg/mg protein).
    • Children over 1 year old had lower platelet and plasma tocopherol concentrations than adults.
    • Infants (<1 year) exhibited higher tocopherol concentrations (platelet, plasma, RBC) comparable to adults, possibly due to fortified formulas.

    Conclusions:

    • The established reference range for platelet tocopherol in children is 0.07-0.39 µg/mg protein.
    • Age-related differences in tocopherol levels exist in children, with infants showing higher concentrations.
    • Higher alpha-tocopherol intake from infant formulas may explain elevated levels in infants.