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Related Experiment Video

Updated: Jun 24, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

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COVID-19-associated Diffuse Leukoencephalopathy and Microhemorrhages.

Alireza Radmanesh¹, Anna Derman¹, Yvonne W Lui¹

¹From the Department of Radiology, New York University Grossman School of Medicine, 660 First Ave, 2nd Floor, New York, NY 10016.

|May 22, 2020

Summary

Critically ill patients with coronavirus disease 2019 (COVID-19) showed specific brain imaging findings. These included white matter changes and microhemorrhages, suggesting neurological complications in severe COVID-19.

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Last Updated: Jun 24, 2026

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

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Published on: June 8, 2017

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Published on: October 17, 2018

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Published on: May 19, 2020

Area of Science:

Neurology
Radiology
Infectious Diseases

Background:

Coronavirus disease 2019 (COVID-19) is linked to various neurological complications.
Brain imaging in COVID-19 patients has revealed findings like infarcts, hemorrhages, and encephalopathy.

Purpose of the Study:

To report and characterize specific brain imaging features in critically ill COVID-19 patients with persistent altered mental status.
To investigate potential pathogeneses of observed neurological findings in severe COVID-19.

Main Methods:

Magnetic Resonance Imaging (MRI) was performed on 11 critically ill COVID-19 patients.
Imaging analysis focused on white matter abnormalities and microhemorrhages.

Main Results:

Ten of 11 patients exhibited confluent T2 hyperintensity and mild restricted diffusion in deep and subcortical white matter.
Seven of 11 patients presented with multiple punctate microhemorrhages in juxtacortical and callosal white matter.

Conclusions:

Diffuse leukoencephalopathy and microhemorrhages are significant brain imaging findings in severe COVID-19.
These findings suggest a potential pattern of neurological injury associated with COVID-19.