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Non-coding RNA in bladder cancer

Yi Li1, Gang Li1, Xiangyang Guo1

  • 1Department of Anesthesiology, Peking University Third Hospital (PUTH), Beijing, China.

Cancer Letters
|May 22, 2020
PubMed

Insights

Non-coding RNAs (ncRNAs) like microRNAs and long non-coding RNAs are linked to bladder cancer development. Understanding these molecules could lead to better diagnostic and treatment options for this common cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer is a significant global health concern, ranking tenth in incidence, with considerable mortality and morbidity.
  • Current treatment strategies for bladder cancer rely on established classifications and gradings, yet patient responses vary significantly, indicating underlying disease heterogeneity.
  • This variability underscores the need for deeper molecular insights to discover novel diagnostic markers and therapeutic targets.

Purpose of the Study:

  • To review recent advancements in understanding the role of non-coding RNAs (ncRNAs) in bladder cancer pathogenesis.
  • To explore the potential of ncRNAs as biomarkers for diagnosis and as therapeutic targets for bladder cancer.

Main Methods:

  • Comprehensive literature review of recent studies on non-coding RNAs (ncRNAs) in bladder cancer.
  • Analysis of findings related to microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in bladder cancer occurrence and progression.

Main Results:

  • Emerging evidence implicates various classes of ncRNAs, including miRNAs, lncRNAs, and circRNAs, in the development and progression of bladder cancer.
  • These ncRNAs exhibit altered expression patterns in bladder cancer, suggesting their involvement in key cellular processes.
  • The specific roles of different ncRNAs in bladder cancer pathogenesis are increasingly being elucidated.

Conclusions:

  • Non-coding RNAs are critically involved in the molecular mechanisms underlying bladder cancer.
  • Further research into ncRNAs offers a promising avenue for developing more precise diagnostic tools and effective therapeutic strategies for bladder cancer.
  • Targeting ncRNAs may represent a future direction for personalized medicine in bladder cancer treatment.
Keywords:
Bladder cancerDiagnosisNon-coding RNAs

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