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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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RNA Splicing01:32

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Related Experiment Video

Updated: Dec 20, 2025

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
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An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

Published on: July 28, 2012

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Non-coding RNA in bladder cancer.

Yi Li1, Gang Li1, Xiangyang Guo1

  • 1Department of Anesthesiology, Peking University Third Hospital (PUTH), Beijing, China.

Cancer Letters
|May 22, 2020
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) like microRNAs and long non-coding RNAs are linked to bladder cancer development. Understanding these molecules could lead to better diagnostic and treatment options for this common cancer.

Keywords:
Bladder cancerDiagnosisNon-coding RNAs

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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
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An Orthotopic Bladder Cancer Model for Gene Delivery Studies
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An Orthotopic Bladder Cancer Model for Gene Delivery Studies

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Bladder cancer is a significant global health concern, ranking tenth in incidence, with considerable mortality and morbidity.
  • Current treatment strategies for bladder cancer rely on established classifications and gradings, yet patient responses vary significantly, indicating underlying disease heterogeneity.
  • This variability underscores the need for deeper molecular insights to discover novel diagnostic markers and therapeutic targets.

Purpose of the Study:

  • To review recent advancements in understanding the role of non-coding RNAs (ncRNAs) in bladder cancer pathogenesis.
  • To explore the potential of ncRNAs as biomarkers for diagnosis and as therapeutic targets for bladder cancer.

Main Methods:

  • Comprehensive literature review of recent studies on non-coding RNAs (ncRNAs) in bladder cancer.
  • Analysis of findings related to microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in bladder cancer occurrence and progression.

Main Results:

  • Emerging evidence implicates various classes of ncRNAs, including miRNAs, lncRNAs, and circRNAs, in the development and progression of bladder cancer.
  • These ncRNAs exhibit altered expression patterns in bladder cancer, suggesting their involvement in key cellular processes.
  • The specific roles of different ncRNAs in bladder cancer pathogenesis are increasingly being elucidated.

Conclusions:

  • Non-coding RNAs are critically involved in the molecular mechanisms underlying bladder cancer.
  • Further research into ncRNAs offers a promising avenue for developing more precise diagnostic tools and effective therapeutic strategies for bladder cancer.
  • Targeting ncRNAs may represent a future direction for personalized medicine in bladder cancer treatment.