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Cardiac injuries in patients with coronavirus disease 2019: Not to be ignored

Hua Fan1, Lin Zhang1, Bin Huang2

  • 1Department of Intensive Care Medicine, The First Affiliated Hospital of, USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|May 22, 2020
PubMed

Insights

Older patients with COVID-19 (coronavirus disease 2019) who experienced cardiac injury showed higher mortality. Elevated hs-Troponin I (hs-TnI) levels indicated a poor prognosis, potentially linked to inflammation and coagulation issues.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Cardiology

Background:

  • Coronavirus disease 2019 (COVID-19) is a global health crisis.
  • Understanding the clinical manifestations and prognostic factors of COVID-19 is crucial for patient management.
  • Cardiac involvement in COVID-19 patients requires further investigation.

Purpose of the Study:

  • To elucidate the clinical features of COVID-19 patients.
  • To identify predictors of mortality in COVID-19.
  • To explore the role of cardiac injury in COVID-19 outcomes.

Main Methods:

  • Retrospective analysis of 73 intensive care unit (ICU) patients with COVID-19.
  • Collected demographic, comorbidity, and laboratory data upon admission.
  • Compared clinical characteristics and outcomes between survivors and non-survivors.

Main Results:

  • Non-survivors were older and had more comorbidities than survivors.
  • Elevated C-reactive protein, interleukin-6, D-dimer, and hs-Troponin I (hs-TnI) were observed in non-survivors.
  • Higher hs-TnI levels correlated with shorter survival time and increased mortality risk, though this association weakened after adjusting for inflammatory and coagulation markers.

Conclusions:

  • Cardiac injury is a significant early complication of COVID-19, associated with increased mortality.
  • Inflammatory factor cascade and coagulation abnormalities are potential mechanisms underlying COVID-19-related cardiac injury.
Abstract

Keywords:
COVID-19Cardiac injurycoronavirus diseasesevere acute respiratory syndrome coronavirus 2

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