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Target the human Alanine/Serine/Cysteine Transporter 2(ASCT2): Achievement and Future for Novel Cancer Therapy
Hongli Jiang1, Ning Zhang1, Tongzhong Tang1
1Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Abstract:
Glutamine metabolism, described as major energy and building blocks supply to cell growth, has gained great attention. Alanine-Serine-Cysteine Transporter (ASCT2), which belongs to solute carried (SLC) family transporters and is encoded by the SLC1A5 gene serves as a significant role for glutamine transport. Indeed, ASCT2 is often overexpressed in highly proliferative cancer cells to fulfill enhanced glutamine demand. So far, ASCT2 has been proved to be a significant target during the carcinogenesis process, and emerging evidence reveals that ASCT2 inhibitors can provide a benefit strategy for cancer therapy. Herein, we describe the structure of ASCT2, and summarize its related regulatory factors which are associated with antitumor activity. Moreover, this review article highlights the remarkable reform of discovery and development for ASCT2 inhibitors. On the basis of case studies, our perspectives for targeting ASCT2 and development of ASCT2 antagonist are discussed in the final part.
Insights
Alanine-Serine-Cysteine Transporter 2 (ASCT2) is crucial for cancer cell growth. Inhibiting ASCT2 offers a promising strategy for developing new cancer therapies.
Area of Science:
- Cellular metabolism
- Cancer biology
- Drug discovery
Background:
- Glutamine metabolism is vital for cell growth, providing energy and building blocks.
- Alanine-Serine-Cysteine Transporter 2 (ASCT2), encoded by SLC1A5, is a key transporter for glutamine uptake.
- ASCT2 is frequently overexpressed in cancer cells to meet their high glutamine demands.
Purpose of the Study:
- To review the structure and regulatory factors of ASCT2.
- To highlight the development of ASCT2 inhibitors for cancer therapy.
- To discuss future perspectives on targeting ASCT2.
Main Methods:
- Literature review of ASCT2 structure and function.
- Analysis of regulatory factors impacting ASCT2.
- Summary of ASCT2 inhibitor discovery and development.
Main Results:
- ASCT2 plays a significant role in cancer cell proliferation.
- ASCT2 inhibitors show potential as a therapeutic strategy.
- Regulatory factors associated with ASCT2 influence antitumor activity.
Conclusions:
- ASCT2 is a validated target in cancer therapy.
- Further research into ASCT2 inhibitors is warranted.
- Targeting ASCT2 presents a promising avenue for novel cancer treatments.
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