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Updated: Dec 20, 2025
Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
Intravesical prostatic protrusion does not compromise the therapeutic effects of Mirabegron in male patients with
Yuan C Shen1, Hung J Wang1, Wei C Lee1
1Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Aims:
Intravesical prostatic protrusion (IPP) is associated with the degree of benign prostatic obstruction. We evaluated the effects of Mirabegron, a selective β3 adrenoceptor agonist, on overactive bladder (OAB) in male patients with different degrees of IPP.
Methods:
About 185 male patients ≥40 years with lower urinary tract symptoms were recruited from a tertiary referral center. OAB was defined by the overactive bladder symptom score (OABSS) urgency score of ≥2 and sum score of ≥3. IPP was measured in the midsagittal section using transrectal ultrasound and patients were divided into IPP ≤5 mm and IPP >5 mm groups. Outcomes were assessed at the baseline, 4, and 12 weeks.
Results:
About 104 patients (56.2%) were diagnosed with OAB and received Mirabegron (50 mg) daily use. Both IPP groups (≤5 and >5 mm) had similar baseline OABSS and International Prostate Symptom Scores (IPSS). Four-week Mirabegron usage was associated with significant decreases in both symptom score measurements, OABSS: IPP ≤5 mm -27.4% and IPP >5 mm -19.7% (P = .419) and IPSS: -32% and -22.5% (P = .202), respectively. Urgency, urge incontinence, and nocturia sub-scores were decreased in both groups, -26.3% and -27.4% (P = .690), 53.3% and 46.2% (P = .916), and 20.8% and 15.4% (P = .958). Effects were maintained at 12 weeks. We found no significant improvement in the frequency sub-score in either group. One patient stopped medication because of intolerable hypertension. Most frequent adverse event was increased residual urine (≥50 mL higher than baseline), IPP ≤5 mm 9.2% and IPP >5 mm 5.1% (P = .707), but no case had acute urinary retention.
Conclusions:
Mirabegron is an effective drug to treat male OAB regardless of IPP grade.
Insights
Mirabegron effectively treats overactive bladder (OAB) in men, regardless of intravesical prostatic protrusion (IPP) severity. This study shows significant symptom improvement in OAB patients with both low and high IPP degrees.
Area of Science:
- Urology
- Pharmacology
- Geriatrics
Background:
- Intravesical prostatic protrusion (IPP) correlates with benign prostatic obstruction severity.
- Overactive bladder (OAB) significantly impacts quality of life in affected individuals.
Purpose of the Study:
- To assess the efficacy of Mirabegron, a selective β3 adrenoceptor agonist, in treating OAB symptoms in male patients.
- To evaluate if the degree of intravesical prostatic protrusion (IPP) influences Mirabegron's effectiveness in men with OAB.
Main Methods:
- 185 male patients aged 40+ with lower urinary tract symptoms were enrolled.
- OAB diagnosis was based on OAB Symptom Score (OABSS) urgency and total scores.
- Patients were categorized into IPP ≤5 mm and IPP >5 mm groups based on transrectal ultrasound measurements.
Main Results:
- 104 patients diagnosed with OAB received Mirabegron 50 mg daily.
- Mirabegron significantly reduced OABSS and International Prostate Symptom Scores (IPSS) in both IPP groups after 4 weeks, with sustained effects at 12 weeks.
- Improvements were noted in urgency, urge incontinence, and nocturia, but not frequency. Increased residual urine was the most common adverse event, with no cases of acute urinary retention.
Conclusions:
- Mirabegron demonstrates effectiveness in treating male OAB patients.
- The therapeutic benefits of Mirabegron for OAB symptoms are independent of the patient's intravesical prostatic protrusion grade.
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