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Updated: Dec 20, 2025

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
Two-Phase Dibromocyclopropanation of Unsaturated Alcohols Using Flow Chemistry
Runa Berg Østby1, Terje Didriksen2, Simen Gjelseth Antonsen3
1Faculty of Engineering, Østfold University College, P.O. Box 700, NO-1757 Halden, Norway.
Abstract:
Dibromocyclopropanations are conventionally done by addition of dibromocarbene to alkenes under phase-transfer conditions in batch reactions using a strong base (50% NaOH (aq)), vigorous stirring and long reaction times. We have shown that cyclopropanation of unsaturated alcohols can be done under ambient conditions using continuous flow chemistry with 40% (w/w) NaOH (aq) as the base. The reactions were generally rapid; the yields were comparable to yields reported in the literature for the conventional batch reaction.
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