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Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...

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What Is Organized Screening and What Is Its Value?

Jason A Dominitz¹, Theodore R Levin²

¹Veterans Health Administration, University of Washington School of Medicine, Seattle, WA, USA.

Gastrointestinal Endoscopy Clinics of North America

|May 23, 2020

Summary

Organized colorectal cancer (CRC) screening programs improve participation and reduce mortality. These structured programs allow for systematic assessment and intervention to optimize CRC outcomes.

Keywords:

Cancer screening Colonoscopy Colorectal neoplasms Mass screening Occult blood Patient navigation

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Area of Science:

Public Health
Cancer Screening
Health Services Research

Background:

Colorectal cancer (CRC) screening in the US is largely opportunistic.
Organized screening programs exist within some integrated health care systems.

Purpose of the Study:

To describe the components of organized CRC screening.
To highlight the benefits of organized screening for optimizing CRC outcomes.

Main Methods:

Defined organized CRC screening by its key components: policy, population, team, delivery, quality assurance, and outcome identification.
Reviewed evidence on the impact of organized screening.

Main Results:

Organized CRC screening involves a defined structure and processes.
Evidence suggests organized screening improves participation rates.
Organized screening is linked to reduced CRC mortality.

Conclusions:

Organized screening provides a framework for systematic evaluation and improvement of CRC screening programs.
Implementation of organized screening is associated with better population health outcomes regarding CRC.