Related Experiment Videos
Bioavailability of potassium from three dosage forms: suspension, capsule, and solution
A P Melikian1, L K Cheng, G J Wright
1Drug Metabolism Department, A. H. Robins Co., Richmond, Virginia 23261-6609.
Journal of Clinical Pharmacology
|November 1, 1988
Summary
This study found that microencapsulated potassium chloride suspension and capsules offer comparable potassium bioavailability to liquid potassium chloride. All formulations demonstrated full potassium absorption, with no significant differences observed between the suspension and capsules.
Area of Science:
- Pharmacokinetics
- Nutritional Science
- Drug Delivery Systems
Background:
- Potassium chloride (KCl) is essential for physiological functions.
- Ensuring adequate potassium intake is crucial, especially for individuals with potassium deficiencies.
- Microencapsulation technology aims to control the release and improve the bioavailability of active ingredients like KCl.
Purpose of the Study:
- To compare the bioavailability of potassium from a novel microencapsulated KCl suspension against a marketed microencapsulated KCl capsule and a KCl solution.
- To evaluate the absorption rate and extent of potassium from different KCl formulations in healthy volunteers.
Main Methods:
- A randomized, four-period crossover study was conducted in 28 healthy male volunteers.
- Participants received controlled diets with fixed potassium and sodium intake.
- Potassium bioavailability was assessed by measuring cumulative urinary potassium (K+) excretion at 24 and 48 hours post-administration.
Main Results:
- Potassium absorption from the suspension and capsules was slower and more sustained compared to the liquid solution, indicating controlled release.
- No statistically significant differences in bioavailability were found between the microencapsulated KCl suspension and the marketed KCl capsule.
- The extent of potassium absorption was similar across all three formulations, with the suspension demonstrating full bioavailability relative to the liquid and capsule.
Conclusions:
- Microencapsulated potassium chloride suspension provides comparable and complete potassium bioavailability to conventional KCl formulations.
- The controlled-release characteristics of the suspension and capsules prevent rapid potassium "dumping."
- This microencapsulated suspension represents a viable alternative for potassium supplementation, ensuring effective absorption.