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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Design and synthesis of a new furan-steroid-propanone derivative using some chemical strategies
Figueroa-Valverde Lauro1, Rosas-Nexticapa Marcela2, Lopez-Ramos Maria1
1Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Ex Hacienda Kalá s/n, 24085 San Francisco de Campeche, Mexico.
Abstract:
There are several reports for the preparation of furan derivatives using some protocols which requires special conditions. In this way, the aim of this study was to synthesize a new furan-steroid-propanone derivative from both 17α-ethynylestradiol and 2-nitro-17α-ethynylestradiol using some series of reactions such as aldolization, 2 + 2 addition and etherification. The chemical structure was evaluated through both 1H NMR and 13C NMR spectroscopic analysis. The results showed a good yielding from furan-steroid derivative. In conclusion, this investigation provides a facile synthesis of a new furan-steroid-propanone derivative, using some reagents which are not expensive and do not require special conditions for handling.
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