Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

644
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
644
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

361
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
361
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

259
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
259
Inflammation01:38

Inflammation

61.1K
Overview
61.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

278
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
278
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

266
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
266

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual responsive enzyme mimicking activity of AgX (X=Cl, Br, I) nanoparticles and its application for cancer cell detection.

ACS applied materials & interfaces·2014
Same author

Naphthoquinone-directed C-H annulation and C(sp³)-H bond cleavage: one-pot synthesis of tetracyclic naphthoxazoles.

The Journal of organic chemistry·2014
Same author

Pulmonary toxicity in mice following exposure to cerium chloride.

Biological trace element research·2014
Same author

Role of surgery in the treatment of patients with high-risk neuroblastoma who have a poor response to induction chemotherapy.

Journal of pediatric surgery·2014
Same author

Glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1) and acute leukemia risk in Asians: a meta-analysis.

Asian Pacific journal of cancer prevention : APJCP·2014
Same author

Influence of casting solvent on phenyl ordering at the surface of spin cast polymer thin films.

Journal of colloid and interface science·2014
Same journal

Reference intervals for venous blood gas measurement in a healthy Chinese population.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Multiplex methylation marker analysis for ctDNA detection in liquid biopsies from anal cancer patients: an HPV-independent approach.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Development and validation of patient-based exponentially weighted moving average quality control models for three antipsychotic drugs and their metabolites by LC-MS/MS.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Comparing conventional correction formulas and machine learning-based prediction of ionized calcium.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Micro- and nanoplastics as emerging clinical analytes: analytical validation, interpretive uncertainty, and laboratory actionability in human specimens.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Performance of Free Light Chain reagents in the Dutch External Quality Assessment programme over the past 14 years.

Clinica chimica acta; international journal of clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: Dec 20, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.6K

SUMOylation in atherosclerosis.

Yi-Zhang Liu1, Xuan Xiao1, Chu-Ting Hu2

  • 1Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Research Lab for Clinical & Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Departments of Clinical Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|May 23, 2020
PubMed
Summary
This summary is machine-generated.

SUMOylation, a protein modification, plays a key role in atherosclerosis (AS) development. This process impacts endothelial cell dysfunction, dyslipidemia, and vascular smooth muscle cell proliferation in AS.

Keywords:
AtherosclerosisDyslipidemiaEndothelial cellSUMOVascular smooth muscle cells

More Related Videos

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.7K
Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

10.4K

Related Experiment Videos

Last Updated: Dec 20, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.6K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.7K
Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
07:36

Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice

Published on: September 26, 2018

10.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Atherosclerosis (AS) is a major cause of cardiovascular diseases.
  • Post-translational modifications (PTMs) are increasingly recognized for their role in AS pathogenesis.
  • SUMOylation, a specific PTM, has emerged as a potential contributor to AS.

Purpose of the Study:

  • To review the molecular mechanisms of SUMOylation in atherosclerosis.
  • To elucidate the role of SUMOylation in endothelial cell dysfunction, dyslipidemia, and VSMC proliferation.
  • To enhance understanding of AS pathophysiology through the lens of SUMOylation.

Main Methods:

  • Literature review of studies on SUMOylation and atherosclerosis.
  • Analysis of molecular pathways linking SUMOylation to AS hallmarks.
  • Synthesis of current evidence on SUMOylation's impact on cellular processes in AS.

Main Results:

  • SUMOylation is implicated in endothelial cell dysfunction.
  • SUMOylation influences lipid metabolism, contributing to dyslipidemia.
  • SUMOylation affects vascular smooth muscle cell proliferation, a key feature of AS.

Conclusions:

  • SUMOylation is a significant molecular player in the initiation and progression of atherosclerosis.
  • Targeting SUMOylation pathways may offer novel therapeutic strategies for AS.
  • Further research into SUMOylation's role is crucial for understanding cardiovascular disease.