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The effect of iodide depletion and supplementation in the Buffalo strain rat
1University of Cambridge, Department of Medicine, United Kingdom.
We have investigated the effect of excess iodide alone, following iodide depletion or in conjunction with a mild thyroid insult (trypan blue) in Buffalo strain rats, which are genetically susceptible to experimental autoimmune thyroiditis. In all three cases a high iodine diet led to enhanced thyroglobulin antibody production, usually accompanied by worsening of the severity of thyroiditis. Moreover, the administration of a normal iodine diet after iodide depletion resulted in thyroglobulin antibody formation. These results provide further support for a role for dietary iodine in modulating experimental autoimmune thyroiditis with implications for human thyroid autoimmunity.
We have investigated the effect of excess iodide alone, following iodide depletion or in conjunction with a mild thyroid insult (trypan blue) in Buffalo strain rats, which are genetically susceptible to experimental autoimmune thyroiditis. In all three cases a high iodine diet led to enhanced thyroglobulin antibody production, usually accompanied by worsening of the severity of thyroiditis. Moreover, the administration of a normal iodine diet after iodide depletion resulted in thyroglobulin antibody formation. These results provide further support for a role for dietary iodine in modulating experimental autoimmune thyroiditis with implications for human thyroid autoimmunity.