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The Role of DLLs in Cancer: A Novel Therapeutic Target

Meng-Xi Xiu1, Yuan-Meng Liu1, Bo-Hai Kuang1

  • 1Medical School of Nanchang University, Nanchang, People's Republic of China.

Oncotargets and Therapy
|May 23, 2020
PubMed

Insights

Delta-like ligands (DLLs) regulate cancer progression by affecting tumor growth, vasculature, and immunity. This review explores DLL roles in cancer and emerging therapeutic targeting strategies for anti-cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Delta-like ligands (DLLs) are key regulators of Notch signaling pathways.
  • Aberrant DLL expression (DLL1, DLL3, DLL4) is implicated in various cancers.
  • DLLs impact critical aspects of tumor biology, including growth, angiogenesis, and immune evasion.

Purpose of the Study:

  • To review the multifaceted roles of DLLs in cancer progression.
  • To summarize current and emerging therapeutic strategies targeting DLLs for cancer treatment.

Main Methods:

  • Literature review of studies on DLLs in cancer.
  • Analysis of the impact of DLLs on tumor growth, vasculature, and immunity.
  • Summary of DLL-targeting therapeutic approaches.

Main Results:

  • DLLs significantly influence tumor growth, angiogenesis, and the tumor immune microenvironment.
  • Dysregulation of DLLs is a common feature in many malignancies.
  • DLL-based therapies show promise as novel anti-cancer treatments.

Conclusions:

  • DLLs are critical mediators of cancer development and progression.
  • Targeting DLLs represents a promising therapeutic avenue for various cancers.
  • Further research into DLL-targeting strategies is warranted to improve anti-cancer efficacy.
Keywords:
cancerdelta-like ligandsnotch signalingtherapy

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