Risk Factors for Prostate Volume Progression After Prostate-Transurethral Resection

Area of Science:

• Urology
• Andrology
• Oncology

Background:

• Benign prostate hypertrophy (BPH) is common in aging men.
• Transurethral resection of the prostate (TURP) is a standard treatment for BPH.
• Residual BPH volume after TURP can be influenced by various factors, including inflammation and hormonal levels.

Purpose of the Study:

• To investigate the risk factors associated with prostate volume progression after TURP.
• To determine the role of tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), serum prostate-specific antigen (PSA), serum testosterone, and age in BPH recurrence post-TURP.

Main Methods:

• Prospective cohort study involving 83 BPH patients undergoing TURP.
• Trans-rectal ultrasonography (TRUS) used to measure prostate size at baseline and three years post-surgery.
• Statistical analysis included Pearson's, Spearman's correlation, and multivariate linear regression.

Main Results:

• Age, testosterone, PSA, TNF-α, and TGF-β showed positive correlations with prostate volume progression.
• Strong correlations were observed between prostate volume and age (r=0.749), PSA (r=0.896), and testosterone (r=0.818).
• TGF-β (r=0.609) and TNF-α (r=0.392) also correlated with prostate volume progression, with TNF-α showing a weaker association.

Conclusions:

• Age, testosterone levels, PSA, TNF-α, and TGF-β are significant risk factors for prostate volume progression post-TURP.
• These findings highlight the multifactorial nature of BPH recurrence.
• Further research may explore targeted interventions based on these identified risk factors.