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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

662
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
662

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A self-adhesive microneedle patch with drug loading capability through swelling effect.

Sharon W T Chew1,2, Ankur H Shah3, Mengjia Zheng1

  • 1School of Chemical and Biomedical Engineering Nanyang Technological University Singapore.

Bioengineering & Translational Medicine
|May 23, 2020
PubMed
Summary
This summary is machine-generated.

This study introduces a versatile hydrogel microneedle (MN) patch for transdermal drug delivery. This platform enables efficient drug loading and release, overcoming limitations of current microneedle fabrication methods.

Keywords:
bioadhesivedendrimermicroneedlesself‐adhesivetransdermal drug delivery

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Microneedles (MNs) enable rapid transdermal drug delivery by penetrating the stratum corneum.
  • Current MN fabrication methods are often drug-specific, hindering commercial translation.
  • A need exists for a broadly applicable MN platform for diverse therapeutic agents.

Purpose of the Study:

  • To develop a versatile hydrogel microneedle platform for transdermal drug delivery.
  • To demonstrate drug loading and release of various therapeutic types using a swelling-based method.
  • To enhance MN adhesion and loading capacity through post-fabrication modifications.

Main Methods:

  • Fabrication of hydrogel microneedles from methacrylated hyaluronic acid (MeHA).
  • Post-fabrication drug loading utilizing the swelling effect of the hydrogel matrix.
  • Incorporation of dendrimer bioadhesives for improved skin adhesion and additional drug loading.

Main Results:

  • Successful loading and burst release of hydrophilic, hydrophobic small molecules, and biomacromolecules from MeHA MNs.
  • Achieved drug loading of 10 μg cm⁻² in MeHA MN patches via post-fabrication loading.
  • Dendrimer bioadhesives enhanced MN work of adhesion for stable skin fixation and enabled further drug loading.

Conclusions:

  • The MeHA hydrogel MN platform offers a broadly applicable approach for transdermal drug delivery.
  • Post-fabrication drug loading via swelling is effective for diverse therapeutics.
  • Dendrimer bioadhesives represent a promising strategy for improving MN performance and versatility.