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Updated: Dec 20, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Hydrogels in the clinic.

Abhirup Mandal^1,2, John R Clegg^1,2, Aaron C Anselmo³

¹John A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts USA.

Bioengineering & Translational Medicine

|May 23, 2020

Summary

This summary is machine-generated.

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Injectable hydrogels show great promise in drug delivery and tissue engineering, with many already approved for healthcare uses. Further research is exploring their potential in regenerative medicine and other clinical applications.

Area of Science:

Biomaterials Science
Polymer Chemistry
Regenerative Medicine

Background:

Injectable hydrogels are versatile biomaterials extensively studied for drug delivery and tissue engineering.
Advances in materials science, polymer chemistry, and fabrication strategies have expanded hydrogel applications.
Numerous hydrogel technologies have gained regulatory approval for diverse healthcare applications.

Purpose of the Study:

To analyze the current clinical landscape of injectable hydrogel technologies.
To identify key clinical areas where hydrogels have achieved success.
To discuss challenges hindering broader clinical translation.

Main Methods:

Review of clinically approved injectable hydrogel technologies.
Analysis of hydrogels currently under clinical investigation.

Keywords:

FDA clinics drug delivery injectable materials marketed products regenerative translational medicine

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Synthesis of information on hydrogel applications in healthcare.

Main Results:

Injectable hydrogels have demonstrated success in areas such as cancer treatment, aesthetic corrections, and spinal fusion.
Ongoing clinical investigations focus on tissue regeneration, incontinence, and other therapeutic applications.
The tunable nature of hydrogels allows for tailored properties for specific medical needs.

Conclusions:

Injectable hydrogels represent a significant advancement in medical technology with established clinical successes.
Continued innovation in polymer science and engineering will likely drive new hydrogel applications.
Addressing challenges in clinical translation is crucial for realizing the full potential of hydrogels in healthcare.